Therapies to normalise cancer cells

A new study promises to make cancer treatment more tolerable and successful by focusing on therapies that could help cancer cells get back to normal, in addition to strategies for killing them. 

A team of researchers  used the latest gene sequencing tools to examine the so-called epigenetic influences on the DNA makeup of colon cancer. They focused on a particular epigenetic biochemical signature known as methylation, which silences the genes.

By comparing the epigenomes of eight human tissue samples, three from non-cancerous colon tissue, three from colon tumours and two from polyps (early-stage colon cancer), the team found that in all the colon tumours the defining characteristic was a universally “chaotic” pattern of methylation. Read more…


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