ZALTRAP™, CTNNB1 improve survival.

Two colorectal cancer studies released results on a new drug and a new biomarker. ZALTRAP™ shows promise as a second-line treatment of late stage disease. Examination of CTNNB1, a biomarker, revealed insights into a protein interaction that may explain increased survival in some obese colorectal cancer patients.

VELOUR trial evaluating the investigational agent ZALTRAP™ (aflibercept) in combination FOLFIRI [folinic acid (leucovorin), 5-fluorouracil, and irinotecan] versus a regimen of FOLFIRI plus placebo showed improvement in overall survival (OS.) OS was the study’s primary endpoint, aimed at the second-line treatment of metastatic colorectal cancer (mCRC). ZALTRAP™ is also known as VEGF Trap. Read more…

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