Zebrafish offers skin cancer clues

Zebrafish has offered new hope to people with melanoma, an aggressive form of skin cancer.Researchers identified SETDB1 as a new gene that promotes the growth of melanoma and may play a role in up to 70 per cent of malignant melanomas.

The researchers screened more than 3,000 zebrafish and found one gene that dramatically accelerated melanoma formation: SETDB1, which encodes a histone methyltransferase enzyme. Fish melanomas with elevated levels of SETDB1 are highly invasive and have a set of deregulated genes that are present in human tumors with high levels of SETDB1. Read more…

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