Mutated Gene Found in Patients with Renal Cancer

Renal cancer is among the 10 most common cancers in both men and women.Renal Cell Carcinoma (RCC) accounts for 90% of kidney cancer cases with clear cell RCC (ccRCC) being the most prevalent subtype. Researchers have found a genetic mutation that occurs in one in three patients with this type of cancer, a finding that is critical to finding treatment for the disease.
Team of researchers previously identified the role of the VHL gene and SETD2 in an inherited form of kidney cancer known as sporadic renal cell carcinoma. These three genes are all involved in altering the chromatin structure that holds DNA together and their location allows cancer to reduce the number of genetic events needed to hit and inactivate all three genes. Read more…


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